The 2019-20 Premiership season will start with Bristol hosting West Country rivals Bath on Friday, 18 October.
Champions Saracens will open the defence of their title the following day at home to Northampton.
Last season’s runners-up Exeter host Harlequins on Saturday, with promoted London Irish at Wasps on Sunday.
The campaign begins about six weeks later than usual because of the World Cup, which takes place in Japan from 20 September to 2 November.
It will be the second Premiership season in succession to start at Ashton Gate, with Bristol beating Bath in last year’s curtain-raiser after their promotion back to the top flight.
Opening Premiership fixtures
- Bristol v Bath (19:45 BST, Friday, 18 October)
- Exeter v Harlequins (15:00 BST, Saturday, 19 October)
- Sale v Gloucester (15:00 BST, Saturday, 19 October)
- Saracens v Northampton (15:00 BST, Saturday, 19 October)
- Worcester v Leicester (15:00 BST, Saturday, 19 October)
- Wasps v London Irish (15:00 BST, Sunday, 20 October)
Harlequins have confirmed that their match against Leicester on 28 December will be played at Twickenham, which will also stage the game between Bath and Wasps on 18 April.
Meanwhile, Saracens will take on London rivals Quins at Tottenham Hotspur’s new stadium during the round of fixtures scheduled for 27-29 March.
It is part of an agreement announced in March, which will see the English and European champions play an annual showpiece game at the 62,062-capacity ground.
The first of the heavyweight Premiership derbies sees Leicester go to Northampton in the fifth round of fixtures on 30 November.
Worcester head to Kingsholm to face Gloucester in the first Severn derby of the season on 20 December, with Exeter hosting Saracens on 29 December in a repeat of last season’s final.