The Red Devils must succeed the Austrians to prolong their European adventure, while Wolverhampton will need to navigate a route past the local rival slayer Olympiacos.
The Portuguese guided Manchester United to glory back in 2017, with the Red Devils having endured a barren run on the trophy front since then.
They will, however, be confident of prolonging their continental campaign three years on after being paired with the lowest-ranked side left in the competition, Austrian hopefuls LASK.
Inter are another of those setting their sights on the ultimate prize, with the Serie A heavyweights hoping to see their star-studded squad deliver tangible reward in 2019-20.
The Serie A title challengers were forced to play the second leg of their last-32 clash with Ludogorets behind closed doors due to an outbreak of the coronavirus in northern Italy.
It remains to be seen whether the turnstiles will be in operation again by the time the Nerazzurri take in a meeting with Getafe.
A lively atmosphere can be expected in Greece when Wolves take in a trip to face Olympiacos.
The Athens-based outfit stunned Arsenal in the first knockout round and are now chasing down a second Premier League scalp.
Nuno Espirito Santo has, however, seen Wolves win many admirers during their return to European competition and Molineux will be bouncing for the second leg of an eagerly-anticipated tie.
Fireworks can also be expected at Ibrox when Rangers play host to Bayer Leverkusen.
The Glasgow giants have already progressed further than Old Firm rivals Celtic, who came unstuck against FC Copenhagen in the last 32.
Spanish side Sevilla knows what it takes to progress through the business end of the Europa League and will want to put down another marker to their rivals when tackling Roma.
Wolfsburg will be doing likewise when facing Shakhtar Donetsk, while FC Basel are still waiting to discover who they will face after a storm warning in Austria delayed the second leg of Eintracht Frankfurt’s meeting with Red Bull Salzburg.
All of those left in the competition will be desperate to book a spot in the quarter-finals, while also dreaming of making it all the way to the final in Gdansk on May 27.
The full draw is as follows:
LASK Linz vs Manchester United
Bayer Leverkusen vs Glasgow Rangers
Red Bull Salzburg/Eintracht Frankfurt vs Basel
Istanbul Basaksehir vs FC Copenhagen
Wolverhampton Wanderers vs Olympiacos
Wolfsburg vs Shakhtar Donetsk
Inter vs Getafe
Sevilla vs Roma